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Recording

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2023 International Prophylaxis Study Group (IPSG) Virtual Symposium was held on the 19th of September.

Immune Tolerance Induction (ITI) in the current treatment era

Itinerary

  1. Introduction

    Chair: Dr. Amy Dunn

  2. What we know and what we do not know about the immune response to FVIII in the non-factor replacement era

    Dr. Bhavya S. Doshi

    Division of Haematology, Department of Pediatrics, Children’s Hospital of Philadelphia USA

    Division of Haematology, Department of Pediatrics, Children’s Hospital of Philadelphia

  3. The Atlanta protocol rationale and outcomes

    Shannon L. Meeks, MD, MBA

    Professor of Pediatrics Professor of Pediatrics, The John and Elaine Mitchell Chair in Hemostasis, Emory University, Scientific Director of Hemostasis and Thrombosis Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta USA

    Professor of Pediatrics Professor of Pediatrics, The John and Elaine Mitchell Chair in Hemostasis, Emory University, Scientific Director of Hemostasis and Thrombosis Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta

  4. Is ITI still needed and is it being done - the PedNET experience

    Christoph Königs, MD, PhD

    University Hospital Frankfurt, Department of Pediatrics and Adolescent Medicine, Clinical and Molecular Hemostasis Germany

    University Hospital Frankfurt, Department of Pediatrics and Adolescent Medicine, Clinical and Molecular Hemostasis

  5. Panel Discussion

    Panelists: Bhavya S. Doshi, Shannon L. Meeks, Christoph Königs, Amy Dunn

  6. Closing Remarks

    Chair: Dr. Amy Dunn

Meet Your Speakers

Dr. Amy Dunn

Moderator

Amy Dunn, MD

Amy L. Dunn. MD is a Professor of Pediatrics at Nationwide Children's Hospital/Ohio State University where she is the Director of Pediatric Hematology and directs the Hemophilia Treatment Center. Dr Dunn received her medical degree from Wright State University School of Medicine in Dayton, Ohio and completed her pediatric and pediatric hematology/oncology training at Emory University in Atlanta, Georgia. Dr Dunn is a member of various professional associations including the American Society of Hematology, World Federation of Hemophilia, The International Society of Thrombosis and Hemostasis, the International Prophylaxis Study Group and the Hemophilia and Thrombosis Research Society (HTRS). She is on the board of the World Federation of Hemophilia, USA and the Chair of MASAC for the National Hemophilia Foundation. Dr Dunn has also received multiple awards, including the US News and World Report Top Doctors, and was the National Hemophilia Foundation Physician of the Year for 2020.

Dr. Bhavya S. Doshi

Speaker

Dr. Bhavya S. Doshi

Bhavya Doshi, MD is a Pediatric Hematologist at the Children's Hospital of Philadelphia and an Assistant Professor of Pediatrics at the University of Pennsylvania. She completed her medical training and pediatric residency at Emory University School of Medicine in Atlanta, GA and her pediatric hematology/oncology fellowship at the Children's Hospital of Philadelphia. She specializes in caring for children with bleeding and clotting disorders. Her laboratory research focuses on hemophilia, factor VIII inhibitors, and alloantibody responses to therapeutics. Her clinical research focuses on improving diagnostics for patients with bleeding disorders.

Shannon L. Meeks, MD, MBA

Speaker

Shannon L. Meeks, MD, MBA

Shannon L. Meeks, MD is a pediatric hematologist at the Aflac Cancer and Blood Disorders Center of Children’s Healthcare of Atlanta and Professor of Pediatrics and the Mitchell Chair in Hemostasis at Emory University. She obtained a Bachelor of Science in Mathematics from Duke University. After earning her medical degree at the University of Mississippi in Jackson, she served her residency in pediatrics at the University of Virginia, Charlottesville, and pursued a fellowship in pediatric hematology/oncology at Emory University. Dr. Meeks has a basic, translational, and clinical research interest in hemophilia and inhibitors. Her current projects focus on understanding the early stages of the immune response to factor VIII and understanding how changing patterns of factor VIII exposure in the setting of non-factor replacement therapies impact the immune response to factor VIII . She currently serves as the President of the Hemostasis and Thrombosis Research Society and is a member of the Medical and Scientific Advisory Council (MASAC) of the National Hemophilia Foundation.

Christoph Königs, MD, PhD

Speaker

Christoph Königs, MD, PhD

Christoph Königs is based at the Pediatric Hemophilia Center, University Hospital Frankfurt, Germany since 2002. In addition to closely working with patients and their families at the center, he heads the clinical and molecular hemostasis research group. The research group focuses on coagulation disorders especially on understanding the immune response to coagulation factors and the development of alternative humoral or cellular treatments. He received his medical education and training at the Goethe University in Frankfurt, and his scientific education at the Monash University in Melbourne. Dr Königs has specialized in pediatrics and hemostasis. He received his Habilitation in 2022. He is a member of several scientific societies and committees. He co-leads the national registry on newly diagnosed hemophilias in Germany and the scientific advisory council of PedNet.